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Deregulation of Scribble promotes mammary tumorigenesis and reveals a role for cell polarity in carcinoma

Loss of cell polarity proteins such as Scribble induces neoplasia in Drosophila by promoting uncontrolled proliferation. The role polarity proteins play during tumorigenesis in mammals is poorly understood. We demonstrate that knockdown of Scribble in mammary epithelia disrupts cell polarity, blocks...

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Detalhes bibliográficos
Main Authors: Zhan, Lixing, Rosenberg, Avi, Bergami, Kenneth C., Yu, Min, Xuan, Zhenyu, Jaffe, Aron B., Allred, Craig, Muthuswamy, Senthil K.
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3015046/
https://ncbi.nlm.nih.gov/pubmed/19041750
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2008.09.045
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