THE SPLICING FACTOR SRSF1 REGULATES APOPTOSIS AND PROLIFERATION TO PROMOTE MAMMARY EPITHELIAL CELL TRANSFORMATION

The splicing-factor oncoprotein SRSF1 (also known as SF2/ASF) is upregulated in breast cancers. We investigated SRSF1’s ability to transform human and mouse mammary epithelial cells in vivo and in vitro. SRSF1-overexpressing COMMA-1D cells formed tumors, following orthotopic transplantation to recon...

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Autors principals: Anczuków, Olga, Rosenberg, Avi Z., Akerman, Martin, Das, Shipra, Zhan, Lixing, Karni, Rotem, Muthuswamy, Senthil K., Krainer, Adrian R
Format: Artigo
Idioma:Inglês
Publicat: 2012
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3272117/
https://ncbi.nlm.nih.gov/pubmed/22245967
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.2207
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