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ONCOGENIC SPLICING FACTOR SRSF1 IS A CRITICAL TRANSCRIPTIONAL TARGET OF MYC

The SR protein splicing factor SRSF1 is a potent proto-oncogene that is frequently upregulated in cancer. Here we show that SRSF1 is a direct target of the transcription-factor oncoprotein MYC. These two oncogenes are significantly co-expressed in lung carcinomas, and MYC knockdown downregulates SRS...

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書誌詳細
主要な著者: Das, Shipra, Anczuków, Olga, Akerman, Martin, Krainer, Adrian R.
フォーマット: Artigo
言語:Inglês
出版事項: 2012
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3334311/
https://ncbi.nlm.nih.gov/pubmed/22545246
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2011.12.001
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