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Deregulation of Scribble promotes mammary tumorigenesis and reveals a role for cell polarity in carcinoma
Loss of cell polarity proteins such as Scribble induces neoplasia in Drosophila by promoting uncontrolled proliferation. The role polarity proteins play during tumorigenesis in mammals is poorly understood. We demonstrate that knockdown of Scribble in mammary epithelia disrupts cell polarity, blocks...
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| 主要な著者: | , , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2008
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3015046/ https://ncbi.nlm.nih.gov/pubmed/19041750 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2008.09.045 |
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