Mislocalization of the cell polarity protein Scribble promotes mammary tumorigenesis and is associated with basal breast cancer

Scribble (SCRIB) localizes to cell-cell junctions and regulates establishment of epithelial cell polarity. Loss of expression of SCRIB functions as a tumor suppressor in Drosophila and mammals, conversely, overexpression of SCRIB promotes epithelial differentiation in mammals. Here, we report that S...

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Autori principali: Feigin, Michael E., Akshinthala, S. Dipikaa, Araki, Kiyomi, Rosenberg, Avi Z., Muthuswamy, Lakshmi B., Martin, Bernard, Lehmann, Brian D., Berman, Hal K., Pietenpol, Jennifer A., Cardiff, Robert D., Muthuswamy, Senthil K.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2014
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4096808/
https://ncbi.nlm.nih.gov/pubmed/24662921
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-13-3415
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