Design of nucleotide-mimetic and non-nucleotide inhibitors of the translation initiation factor eIF4E: Synthesis, structural and functional characterisation

Eukaryotic translation initiation factor 4E (eIF4E) is considered as the corner stone in the cap-dependent translation initiation machinery. Its role is to recruit mRNA to the ribosome through recognition of the 5′-terminal mRNA cap structure (m(7)GpppN, where G is guanosine, N is any nucleotide). e...

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Detalhes bibliográficos
Publicado no:Eur J Med Chem
Main Authors: Soukarieh, Fadi, Nowicki, Matthew W., Bastide, Amandine, Pöyry, Tuija, Jones, Carolyn, Dudek, Kate, Patwardhan, Geetanjali, Meullenet, François, Oldham, Neil J., Walkinshaw, Malcolm D., Willis, Anne E., Fischer, Peter M.
Formato: Artigo
Idioma:Inglês
Publicado em: Editions Scientifiques Elsevier 2016
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5111791/
https://ncbi.nlm.nih.gov/pubmed/27592390
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejmech.2016.08.047
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