Soluble Adenylyl Cyclase Regulates Bile Salt‐Induced Apoptosis in Human Cholangiocytes

Anion exchanger 2 (AE2), the principal bicarbonate secretor in the human biliary tree, is down‐regulated in primary biliary cholangitis. AE2 creates a “bicarbonate umbrella” that protects cholangiocytes from the proapoptotic effects of bile salts by maintaining them deprotonated. We observed that kn...

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Bibliographische Detailangaben
Veröffentlicht in:Hepatology
Hauptverfasser: Chang, Jung‐Chin, Go, Simei, de Waart, Dirk R., Munoz‐Garrido, Patricia, Beuers, Ulrich, Paulusma, Coen C., Oude Elferink, Ronald
Format: Artigo
Sprache:Inglês
Veröffentlicht: John Wiley and Sons Inc. 2016
Schlagworte:
Autoimmune, Cholestatic and Biliary Disease
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5111777/
https://ncbi.nlm.nih.gov/pubmed/26991014
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep.28550
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