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Activity of the Bile Salt Export Pump (ABCB11) Is Critically Dependent on Canalicular Membrane Cholesterol Content

Mutations in ATP8B1 cause severe inherited liver disease. The disease is characterized by impaired biliary bile salt excretion (cholestasis), but the mechanism whereby impaired ATP8B1 function results in cholestasis is poorly understood. ATP8B1 is a type 4 P-type ATPase and is a flippase for phospha...

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Main Authors: Paulusma, Coen C., de Waart, D. Rudi, Kunne, Cindy, Mok, Kam S., Elferink, Ronald P. J. Oude
格式: Artigo
語言:Inglês
出版: American Society for Biochemistry and Molecular Biology 2009
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2665118/
https://ncbi.nlm.nih.gov/pubmed/19228692
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M808667200
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