Cardiac arrhythmia in a mouse model of sodium channel SCN8A epileptic encephalopathy

Patients with early infantile epileptic encephalopathy (EIEE) are at increased risk for sudden unexpected death in epilepsy (SUDEP). De novo mutations of the sodium channel gene SCN8A, encoding the sodium channel Na(v)1.6, result in EIEE13 (OMIM 614558), which has a 10% risk of SUDEP. Here, we inves...

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Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Frasier, Chad R., Wagnon, Jacy L., Bao, Yangyang Oliver, McVeigh, Luke G., Lopez-Santiago, Luis F., Meisler, Miriam H., Isom, Lori L.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2016
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5111690/
https://ncbi.nlm.nih.gov/pubmed/27791149
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1612746113
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