PDE1C deficiency antagonizes pathological cardiac remodeling and dysfunction

Cyclic nucleotide phosphodiesterase 1C (PDE1C) represents a major phosphodiesterase activity in human myocardium, but its function in the heart remains unknown. Using genetic and pharmacological approaches, we studied the expression, regulation, function, and underlying mechanisms of PDE1C in the pa...

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Bibliographic Details
Published in:Proc Natl Acad Sci U S A
Main Authors: Knight, Walter E., Chen, Si, Zhang, Yishuai, Oikawa, Masayoshi, Wu, Meiping, Zhou, Qian, Miller, Clint L., Cai, Yujun, Mickelsen, Deanne M., Moravec, Christine, Small, Eric M., Abe, Junichi, Yan, Chen
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2016
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PNAS Plus
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5111646/
https://ncbi.nlm.nih.gov/pubmed/27791092
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1607728113
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