PDE1C deficiency antagonizes pathological cardiac remodeling and dysfunction

Cyclic nucleotide phosphodiesterase 1C (PDE1C) represents a major phosphodiesterase activity in human myocardium, but its function in the heart remains unknown. Using genetic and pharmacological approaches, we studied the expression, regulation, function, and underlying mechanisms of PDE1C in the pa...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Knight, Walter E., Chen, Si, Zhang, Yishuai, Oikawa, Masayoshi, Wu, Meiping, Zhou, Qian, Miller, Clint L., Cai, Yujun, Mickelsen, Deanne M., Moravec, Christine, Small, Eric M., Abe, Junichi, Yan, Chen
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2016
Assuntos:
PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5111646/
https://ncbi.nlm.nih.gov/pubmed/27791092
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1607728113
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