PDE1C deficiency antagonizes pathological cardiac remodeling and dysfunction

Cyclic nucleotide phosphodiesterase 1C (PDE1C) represents a major phosphodiesterase activity in human myocardium, but its function in the heart remains unknown. Using genetic and pharmacological approaches, we studied the expression, regulation, function, and underlying mechanisms of PDE1C in the pa...

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Dades bibliogràfiques
Publicat a:Proc Natl Acad Sci U S A
Autors principals: Knight, Walter E., Chen, Si, Zhang, Yishuai, Oikawa, Masayoshi, Wu, Meiping, Zhou, Qian, Miller, Clint L., Cai, Yujun, Mickelsen, Deanne M., Moravec, Christine, Small, Eric M., Abe, Junichi, Yan, Chen
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2016
Matèries:
PNAS Plus
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5111646/
https://ncbi.nlm.nih.gov/pubmed/27791092
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1607728113
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