A Novel Role of Cyclic Nucleotide Phosphodiesterase 10A in Pathological Cardiac Remodeling and Dysfunction

BACKGROUND—: Heart failure is a leading cause of death worldwide. Cyclic nucleotide phosphodiesterases (PDEs), through degradation of cyclic nucleotides, play critical roles in cardiovascular biology and disease. Our preliminary screening studies have revealed PDE10A upregulation in the diseased hea...

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Bibliografiske detaljer
Udgivet i:Circulation
Main Authors: Chen, Si, Zhang, Yishuai, Lighthouse, Janet K., Mickelsen, Deanne M., Wu, Jiangbin, Yao, Peng, Small, Eric M., Yan, Chen
Format: Artigo
Sprog:Inglês
Udgivet: 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7147986/
https://ncbi.nlm.nih.gov/pubmed/31801360
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCULATIONAHA.119.042178
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