SLIT2/ROBO2 signaling pathway inhibits nonmuscle myosin IIA activity and destabilizes kidney podocyte adhesion

The repulsive guidance cue SLIT2 and its receptor ROBO2 are required for kidney development and podocyte foot process structure, but the SLIT2/ROBO2 signaling mechanism regulating podocyte function is not known. Here we report that a potentially novel signaling pathway consisting of SLIT/ROBO Rho GT...

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Publicado no:JCI Insight
Main Authors: Fan, Xueping, Yang, Hongying, Kumar, Sudhir, Tumelty, Kathleen E., Pisarek-Horowitz, Anna, Rasouly, Hila Milo, Sharma, Richa, Chan, Stefanie, Tyminski, Edyta, Shamashkin, Michael, Belghasem, Mostafa, Henderson, Joel M., Coyle, Anthony J., Salant, David J., Berasi, Stephen P., Lu, Weining
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5111509/
https://ncbi.nlm.nih.gov/pubmed/27882344
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.86934
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