Loss of Roundabout Guidance Receptor 2 (Robo2) in Podocytes Protects Adult Mice from Glomerular Injury by Maintaining Podocyte Foot Process Structure

Roundabout guidance receptor 2 (ROBO2) plays an important role during early kidney development. ROBO2 is expressed in podocytes, inhibits nephrin-induced actin polymerization, down-regulates nonmuscle myosin IIA activity, and destabilizes kidney podocyte adhesion. However, the role of ROBO2 during k...

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Bibliografske podrobnosti
izdano v:Am J Pathol
Main Authors: Pisarek-Horowitz, Anna, Fan, Xueping, Kumar, Sudhir, Rasouly, Hila M., Sharma, Richa, Chen, Hui, Coser, Kathryn, Bluette, Crystal T., Hirenallur-Shanthappa, Dinesh, Anderson, Sarah R., Yang, Hongying, Beck, Laurence H., Bonegio, Ramon G., Henderson, Joel M., Berasi, Stephen P., Salant, David J., Lu, Weining
Format: Artigo
Jezik:Inglês
Izdano: American Society for Investigative Pathology 2020
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7217334/
https://ncbi.nlm.nih.gov/pubmed/32220420
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2019.12.009
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