ML372 blocks SMN ubiquitination and improves spinal muscular atrophy pathology in mice

Spinal muscular atrophy (SMA) is an autosomal recessive neuromuscular disease and one of the leading inherited causes of infant mortality. SMA results from insufficient levels of the survival motor neuron (SMN) protein, and studies in animal models of the disease have shown that increasing SMN prote...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Udgivet i:JCI Insight
Main Authors: Abera, Mahlet B., Xiao, Jingbo, Nofziger, Jonathan, Titus, Steve, Southall, Noel, Zheng, Wei, Moritz, Kasey E., Ferrer, Marc, Cherry, Jonathan J., Androphy, Elliot J., Wang, Amy, Xu, Xin, Austin, Christopher, Fischbeck, Kenneth H., Marugan, Juan J., Burnett, Barrington G.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2016
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5111506/
https://ncbi.nlm.nih.gov/pubmed/27882347
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.88427
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!

Lignende værker