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Modulation of NMDA channel gating by Ca(2+) and Cd(2+) binding to the external pore mouth
NMDA receptor channels are characterized by high Ca(2+) permeability. It remains unclear whether extracellular Ca(2+) could directly modulate channel gating and control Ca(2+) influxes. We demonstrate a pore-blocking site external to the activation gate for extracellular Ca(2+) and Cd(2+), which has...
Gespeichert in:
| Veröffentlicht in: | Sci Rep |
|---|---|
| Hauptverfasser: | , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Nature Publishing Group
2016
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5111045/ https://ncbi.nlm.nih.gov/pubmed/27848984 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep37029 |
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