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Characterization of the Gating Conformational Changes in the Felbamate Binding Site in NMDA Channels
The anticonvulsant effect of felbamate (FBM) is ascribable to inhibition of N-methyl-d-aspartate (NMDA) currents. Using electrophysiological studies in rat hippocampal neurons to examine the kinetics of FBM binding to and unbinding from the NMDA channel, we show that FBM modifies NMDA channel gating...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The Biophysical Society
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1896240/ https://ncbi.nlm.nih.gov/pubmed/17468173 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1529/biophysj.106.098095 |
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