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An Inactivation Stabilizer of the Na(+) Channel Acts as an Opportunistic Pore Blocker Modulated by External Na(+)
The Na(+) channel is the primary target of anticonvulsants carbamazepine, phenytoin, and lamotrigine. These drugs modify Na(+) channel gating as they have much higher binding affinity to the inactivated state than to the resting state of the channel. It has been proposed that these drugs bind to the...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The Rockefeller University Press
2005
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2217501/ https://ncbi.nlm.nih.gov/pubmed/15824190 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1085/jgp.200409156 |
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