Genomic profiling of multiple sequentially acquired tumor metastatic sites from an “exceptional responder” lung adenocarcinoma patient reveals extensive genomic heterogeneity and novel somatic variants driving treatment response

We used next-generation sequencing to identify somatic alterations in multiple metastatic sites from an “exceptional responder” lung adenocarcinoma patient during his 7-yr course of ERBB2-directed therapies. The degree of heterogeneity was unprecedented, with ∼1% similarity between somatic alteratio...

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Detaylı Bibliyografya
Yayımlandı:Cold Spring Harb Mol Case Stud
Asıl Yazarlar: Biswas, Romi, Gao, Shaojian, Cultraro, Constance M., Maity, Tapan K., Venugopalan, Abhilash, Abdullaev, Zied, Shaytan, Alexey K., Carter, Corey A., Thomas, Anish, Rajan, Arun, Song, Young, Pitts, Stephanie, Chen, Kevin, Bass, Sara, Boland, Joseph, Hanada, Ken-Ichi, Chen, Jinqiu, Meltzer, Paul S., Panchenko, Anna R., Yang, James C., Pack, Svetlana, Giaccone, Giuseppe, Schrump, David S., Khan, Javed, Guha, Udayan
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Cold Spring Harbor Laboratory Press 2016
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5111000/
https://ncbi.nlm.nih.gov/pubmed/27900369
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/mcs.a001263
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