Genomic profiling of multiple sequentially acquired tumor metastatic sites from an “exceptional responder” lung adenocarcinoma patient reveals extensive genomic heterogeneity and novel somatic variants driving treatment response

We used next-generation sequencing to identify somatic alterations in multiple metastatic sites from an “exceptional responder” lung adenocarcinoma patient during his 7-yr course of ERBB2-directed therapies. The degree of heterogeneity was unprecedented, with ∼1% similarity between somatic alteratio...

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Pubblicato in:Cold Spring Harb Mol Case Stud
Autori principali: Biswas, Romi, Gao, Shaojian, Cultraro, Constance M., Maity, Tapan K., Venugopalan, Abhilash, Abdullaev, Zied, Shaytan, Alexey K., Carter, Corey A., Thomas, Anish, Rajan, Arun, Song, Young, Pitts, Stephanie, Chen, Kevin, Bass, Sara, Boland, Joseph, Hanada, Ken-Ichi, Chen, Jinqiu, Meltzer, Paul S., Panchenko, Anna R., Yang, James C., Pack, Svetlana, Giaccone, Giuseppe, Schrump, David S., Khan, Javed, Guha, Udayan
Natura: Artigo
Lingua:Inglês
Pubblicazione: Cold Spring Harbor Laboratory Press 2016
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5111000/
https://ncbi.nlm.nih.gov/pubmed/27900369
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/mcs.a001263
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