Genomic profiling of multiple sequentially acquired tumor metastatic sites from an “exceptional responder” lung adenocarcinoma patient reveals extensive genomic heterogeneity and novel somatic variants driving treatment response

We used next-generation sequencing to identify somatic alterations in multiple metastatic sites from an “exceptional responder” lung adenocarcinoma patient during his 7-yr course of ERBB2-directed therapies. The degree of heterogeneity was unprecedented, with ∼1% similarity between somatic alteratio...

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Bibliografski detalji
Izdano u:Cold Spring Harb Mol Case Stud
Glavni autori: Biswas, Romi, Gao, Shaojian, Cultraro, Constance M., Maity, Tapan K., Venugopalan, Abhilash, Abdullaev, Zied, Shaytan, Alexey K., Carter, Corey A., Thomas, Anish, Rajan, Arun, Song, Young, Pitts, Stephanie, Chen, Kevin, Bass, Sara, Boland, Joseph, Hanada, Ken-Ichi, Chen, Jinqiu, Meltzer, Paul S., Panchenko, Anna R., Yang, James C., Pack, Svetlana, Giaccone, Giuseppe, Schrump, David S., Khan, Javed, Guha, Udayan
Format: Artigo
Jezik:Inglês
Izdano: Cold Spring Harbor Laboratory Press 2016
Teme:
Research Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5111000/
https://ncbi.nlm.nih.gov/pubmed/27900369
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/mcs.a001263
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