Targeting the Nrf2 Signaling Pathway in the Retina With a Gene-Delivered Secretable and Cell-Penetrating Peptide

PURPOSE: Oxidative stress has been linked to several ocular diseases, initiating an inflammatory response that increases tissue injury. The Nrf2 transcription factor regulates expression of antioxidant genes and is tightly regulated by Kelch-Like ECH-Associated Protein 1 (Keap-1). We evaluate the an...

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Detalles Bibliográficos
Publicado en:Invest Ophthalmol Vis Sci
Main Authors: Ildefonso, Cristhian J., Jaime, Henrique, Brown, Emily E., Iwata, Ryo L., Ahmed, Chulbul M., Massengill, Michael T., Biswal, Manas R., Boye, Shannon E., Hauswirth, William W., Ash, John D., Li, Qiuhong, Lewin, Alfred S.
Formato: Artigo
Idioma:Inglês
Publicado: The Association for Research in Vision and Ophthalmology 2016
Assuntos:
Biochemistry and Molecular Biology
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5110262/
https://ncbi.nlm.nih.gov/pubmed/26842755
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1167/iovs.15-17703
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