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Use of sequence duplication to engineer a ligand-triggered, long-distance molecular switch in T4 lysozyme
We have designed a molecular switch in a T4 lysozyme construct that controls a large-scale translation of a duplicated helix. As shown by crystal structures of the construct with the switch on and off, the conformational change is triggered by the binding of a ligand (guanidinium ion) to a site that...
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| Hlavní autoři: | , , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
National Academy of Sciences
2004
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC511024/ https://ncbi.nlm.nih.gov/pubmed/15286283 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0404482101 |
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