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Molecular dynamics simulations of an engineered T4 lysozyme exclude helix to sheet transition, and provide insights into long distance, intra‐protein switchable motion

An engineered variant of T4 lysozyme serves as a model for studying induced remote conformational changes in a full protein context. The design involves a duplicated surface helix, flanked by two loops, that switches between two different conformations spanning about 20 Å. Molecular dynamics simulat...

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Publicat a:Protein Sci
Autors principals: Biggers, Laurence, Elhabashy, Hadeer, Ackad, Edward, Yousef, Mohammad S.
Format: Artigo
Idioma:Inglês
Publicat: John Wiley & Sons, Inc. 2019
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6954740/
https://ncbi.nlm.nih.gov/pubmed/31702853
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.3780
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