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The purine scaffold Hsp90 inhibitor PU-H71 sensitizes cancer cells to heavy ion radiation by inhibiting DNA repair by homologous recombination and non-homologous end joining

BACKGROUND AND PURPOSE: PU-H71 is a purine-scaffold Hsp90 inhibitor developed to overcome limitations of conventional Hsp90 inhibitors. This study was designed to investigate the combined effect of PU-H71 and heavy ion irradiation on human tumor and normal cells. MATERIALS AND METHODS: The effects o...

詳細記述

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書誌詳細
出版年:Radiother Oncol
主要な著者: Lee, Younghyun, Li, Huizi, Masaoka, Aya, Sunada, Shigeaki, Hirakawa, Hirokazu, Fujimori, Akira, Nickoloff, Jac A., Okayasu, Ryuichi
フォーマット: Artigo
言語:Inglês
出版事項: 2016
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC5110220/
https://ncbi.nlm.nih.gov/pubmed/27666928
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.radonc.2016.08.029
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