Hepacivirus NS3/4A Proteases Interfere with MAVS Signaling in both Their Cognate Animal Hosts and Humans: Implications for Zoonotic Transmission

Multiple novel members of the genus Hepacivirus have recently been discovered in diverse mammalian species. However, to date, their replication mechanisms and zoonotic potential have not been explored in detail. The NS3/4A serine protease of hepatitis C virus (HCV) is critical for cleavage of the vi...

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Bibliographic Details
Published in:J Virol
Main Authors: Anggakusuma, Brown, Richard J. P., Banda, Dominic H., Todt, Daniel, Vieyres, Gabrielle, Steinmann, Eike, Pietschmann, Thomas
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2016
Subjects:
Cellular Response to Infection
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5110154/
https://ncbi.nlm.nih.gov/pubmed/27654291
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01634-16
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