Hepacivirus NS3/4A Proteases Interfere with MAVS Signaling in both Their Cognate Animal Hosts and Humans: Implications for Zoonotic Transmission

Multiple novel members of the genus Hepacivirus have recently been discovered in diverse mammalian species. However, to date, their replication mechanisms and zoonotic potential have not been explored in detail. The NS3/4A serine protease of hepatitis C virus (HCV) is critical for cleavage of the vi...

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Dades bibliogràfiques
Publicat a:J Virol
Autors principals: Anggakusuma, Brown, Richard J. P., Banda, Dominic H., Todt, Daniel, Vieyres, Gabrielle, Steinmann, Eike, Pietschmann, Thomas
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2016
Matèries:
Cellular Response to Infection
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5110154/
https://ncbi.nlm.nih.gov/pubmed/27654291
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01634-16
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