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Constitutive Activation of DNA Damage Checkpoint Signaling Contributes to Mutant p53 Accumulation via Modulation of p53 Ubiquitination
Many mutant p53 proteins exhibit an abnormally long half-life and overall increased abundance compared to wild-type p53 in tumors, contributing to mutant p53’s gain-of-function oncogenic properties. Here a novel mechanism is revealed for the maintenance of mutant p53 abundance in cancer that is depe...
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| Pubblicato in: | Mol Cancer Res |
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| Autori principali: | , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2016
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5110038/ https://ncbi.nlm.nih.gov/pubmed/26965143 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1541-7786.MCR-15-0363 |
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