Chargement en cours...
Constitutive Activation of DNA Damage Checkpoint Signaling Contributes to Mutant p53 Accumulation via Modulation of p53 Ubiquitination
Many mutant p53 proteins exhibit an abnormally long half-life and overall increased abundance compared to wild-type p53 in tumors, contributing to mutant p53’s gain-of-function oncogenic properties. Here a novel mechanism is revealed for the maintenance of mutant p53 abundance in cancer that is depe...
Enregistré dans:
| Publié dans: | Mol Cancer Res |
|---|---|
| Auteurs principaux: | , , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2016
|
| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5110038/ https://ncbi.nlm.nih.gov/pubmed/26965143 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1541-7786.MCR-15-0363 |
| Tags: |
Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!
|