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Resolution of Site-Specific Conformational Heterogeneity in Proline-Rich Molecular Recognition by Src Homology 3 Domains

Conformational heterogeneity and dynamics are increasingly evoked in models of protein molecular recognition but are challenging to experimentally characterize. Here we combine the inherent temporal resolution of infrared (IR) spectroscopy with the spatial resolution afforded by selective incorporat...

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Detalhes bibliográficos
Publicado no:J Am Chem Soc
Main Authors: Horness, Rachel E., Basom, Edward J., Mayer, John P., Thielges, Megan C.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5110030/
https://ncbi.nlm.nih.gov/pubmed/26784847
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.5b11999
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