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Role of Interfacial Water Molecules in Proline-rich Ligand Recognition by the Src Homology 3 Domain of Abl

The interaction of Abl-Src homology 3 domain (SH3) with the high affinity peptide p41 is the most notable example of the inconsistency existing between the currently accepted description of SH3 complexes and their binding thermodynamic signature. We had previously hypothesized that the presence of i...

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Bibliographic Details
Main Authors: Palencia, Andres, Camara-Artigas, Ana, Pisabarro, M. Teresa, Martinez, Jose C., Luque, Irene
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2010
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2807336/
https://ncbi.nlm.nih.gov/pubmed/19906645
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.048033
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