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Dendritic cell sphingosine-1-phosphate lyase regulates thymic egress
T cell egress from the thymus is essential for adaptive immunity and involves chemotaxis along a sphingosine-1-phosphate (S1P) gradient. Pericytes at the corticomedullary junction produce the S1P egress signal, whereas thymic parenchymal S1P levels are kept low through S1P lyase (SPL)–mediated metab...
Gardado en:
| Publicado en: | J Exp Med |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
The Rockefeller University Press
2016
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5110016/ https://ncbi.nlm.nih.gov/pubmed/27810923 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20160287 |
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