Dendritic cell sphingosine-1-phosphate lyase regulates thymic egress

T cell egress from the thymus is essential for adaptive immunity and involves chemotaxis along a sphingosine-1-phosphate (S1P) gradient. Pericytes at the corticomedullary junction produce the S1P egress signal, whereas thymic parenchymal S1P levels are kept low through S1P lyase (SPL)–mediated metab...

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Bibliografische gegevens
Gepubliceerd in:J Exp Med
Hoofdauteurs: Zamora-Pineda, Jesus, Kumar, Ashok, Suh, Jung H., Zhang, Meng, Saba, Julie D.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: The Rockefeller University Press 2016
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Research Articles
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5110016/
https://ncbi.nlm.nih.gov/pubmed/27810923
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20160287
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