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Dendritic cell sphingosine-1-phosphate lyase regulates thymic egress
T cell egress from the thymus is essential for adaptive immunity and involves chemotaxis along a sphingosine-1-phosphate (S1P) gradient. Pericytes at the corticomedullary junction produce the S1P egress signal, whereas thymic parenchymal S1P levels are kept low through S1P lyase (SPL)–mediated metab...
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| Udgivet i: | J Exp Med |
|---|---|
| Main Authors: | , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
The Rockefeller University Press
2016
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5110016/ https://ncbi.nlm.nih.gov/pubmed/27810923 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20160287 |
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