Novel method to rescue a lethal phenotype through integration of target gene onto the X-chromosome

The loss-of-function mutations of serine protease inhibitor, Kazal type 1 (SPINK1) gene are associated with human chronic pancreatitis, but the underlying mechanisms remain unknown. We previously reported that mice lacking Spink3, the murine homologue of human SPINK1, die perinatally due to massive...

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Published in:Sci Rep
Main Authors: Sakata, Kazuya, Araki, Kimi, Nakano, Hiroyasu, Nishina, Takashi, Komazawa-Sakon, Sachiko, Murai, Shin, Lee, Grace E., Hashimoto, Daisuke, Suzuki, Chigure, Uchiyama, Yasuo, Notohara, Kenji, Gukovskaya, Anna S., Gukovsky, Ilya, Yamamura, Ken-ichi, Baba, Hideo, Ohmuraya, Masaki
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2016
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5109027/
https://ncbi.nlm.nih.gov/pubmed/27845447
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep37200
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