T Cell Immune Deficiency in zap70 Mutant Zebrafish

ZAP70 [zeta-chain (TCR)-associated protein kinase, 70-kDa], is required for T cell activation. ZAP70 deficiencies in humans and null mutations in mice lead to severe combined immune deficiency. Here, we describe a zap70 loss-of-function mutation in zebrafish (zap70(y442)) that was created using tran...

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Detaylı Bibliyografya
Yayımlandı:Mol Cell Biol
Asıl Yazarlar: Moore, John C., Mulligan, Timothy S., Yordán, Nora Torres, Castranova, Daniel, Pham, Van N., Tang, Qin, Lobbardi, Riadh, Anselmo, Anthony, Liwski, Robert S., Berman, Jason N., Sadreyev, Ruslan I., Weinstein, Brant M., Langenau, David M.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Microbiology 2016
Konular:
Articles
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5108876/
https://ncbi.nlm.nih.gov/pubmed/27601584
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00281-16
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