T Cell Immune Deficiency in zap70 Mutant Zebrafish

ZAP70 [zeta-chain (TCR)-associated protein kinase, 70-kDa], is required for T cell activation. ZAP70 deficiencies in humans and null mutations in mice lead to severe combined immune deficiency. Here, we describe a zap70 loss-of-function mutation in zebrafish (zap70(y442)) that was created using tran...

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Detalhes bibliográficos
Publicado no:Mol Cell Biol
Main Authors: Moore, John C., Mulligan, Timothy S., Yordán, Nora Torres, Castranova, Daniel, Pham, Van N., Tang, Qin, Lobbardi, Riadh, Anselmo, Anthony, Liwski, Robert S., Berman, Jason N., Sadreyev, Ruslan I., Weinstein, Brant M., Langenau, David M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2016
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5108876/
https://ncbi.nlm.nih.gov/pubmed/27601584
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00281-16
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