FcγRIIb-SHIP2 axis links Aβ to tau pathology by disrupting phosphoinositide metabolism in Alzheimer's disease model

Amyloid-β (Aβ)-containing extracellular plaques and hyperphosphorylated tau-loaded intracellular neurofibrillary tangles are neuropathological hallmarks of Alzheimer's disease (AD). Although Aβ exerts neuropathogenic activity through tau, the mechanistic link between Aβ and tau pathology remain...

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Bibliografiske detaljer
Udgivet i:eLife
Main Authors: Kam, Tae-In, Park, Hyejin, Gwon, Youngdae, Song, Sungmin, Kim, Seo-Hyun, Moon, Seo Won, Jo, Dong-Gyu, Jung, Yong-Keun
Format: Artigo
Sprog:Inglês
Udgivet: eLife Sciences Publications, Ltd 2016
Fag:
Cell Biology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5106215/
https://ncbi.nlm.nih.gov/pubmed/27834631
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.18691
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