Functional competence of a partially engaged GPCR–β-arrestin complex

G Protein-coupled receptors (GPCRs) constitute the largest family of cell surface receptors and drug targets. GPCR signalling and desensitization is critically regulated by β-arrestins (βarr). GPCR–βarr interaction is biphasic where the phosphorylated carboxyl terminus of GPCRs docks to the N-domain...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Kumari, Punita, Srivastava, Ashish, Banerjee, Ramanuj, Ghosh, Eshan, Gupta, Pragya, Ranjan, Ravi, Chen, Xin, Gupta, Bhagyashri, Gupta, Charu, Jaiman, Deepika, Shukla, Arun K.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5105198/
https://ncbi.nlm.nih.gov/pubmed/27827372
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms13416
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