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Atg8 lipidation is coordinated in a PtdIns3P-dependent manner by the PROPPIN Atg21
In Saccharomyces cerevisiae Atg8 coupled to phosphatidylethanolamine is a key component of autophagosome biogenesis. Atg21 binds via 2 sites at the circumference of its β-propeller to PtdIns3P at the phagophore assembly site (PAS). It recruits and arranges both Atg8 and Atg16, which is part of the E...
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| Pubblicato in: | Autophagy |
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| Autori principali: | , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Taylor & Francis
2016
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5103337/ https://ncbi.nlm.nih.gov/pubmed/27560294 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15548627.2016.1221564 |
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