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Relb acts downstream of medullary thymic epithelial stem cells and is essential for the emergence of RANK(+) medullary epithelial progenitors

Thymic epithelial cells (TECs) provide essential signals for αβT‐cell development, and medullary TECs (mTECs) control T‐cell tolerance through both negative selection and Foxp3(+) regulatory T (Treg) cell development. Although heterogeneity within the mTEC compartment is well studied, the molecular...

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Detalles Bibliográficos
Publicado en:Eur J Immunol
Main Authors: Baik, Song, Sekai, Miho, Hamazaki, Yoko, Jenkinson, William E., Anderson, Graham
Formato: Artigo
Idioma:Inglês
Publicado: John Wiley and Sons Inc. 2016
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5102679/
https://ncbi.nlm.nih.gov/pubmed/26806881
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/eji.201546253
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