Autophagy Promoted the Degradation of Mutant ATXN3 in Neurally Differentiated Spinocerebellar Ataxia-3 Human Induced Pluripotent Stem Cells

Spinocerebellar ataxia-3 (SCA3) is the most common dominant inherited ataxia worldwide and is caused by an unstable CAG trinucleotide expansion mutation within the ATXN3 gene, resulting in an expanded polyglutamine tract within the ATXN3 protein. Many in vitro studies have examined the role of autop...

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Detalhes bibliográficos
Publicado no:Biomed Res Int
Main Authors: Ou, Zhanhui, Luo, Min, Niu, Xiaohua, Chen, Yuchang, Xie, Yingjun, He, Wenyin, Song, Bing, Xian, Yexing, Fan, Di, OuYang, Shuming, Sun, Xiaofang
Formato: Artigo
Idioma:Inglês
Publicado em: Hindawi Publishing Corporation 2016
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5099487/
https://ncbi.nlm.nih.gov/pubmed/27847820
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2016/6701793
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