The Combination of CRISPR/Cas9 and iPSC Technologies in the Gene Therapy of Human β-thalassemia in Mice

β-thalassemia results from point mutations or small deletions in the β-globin (HBB) gene that ultimately cause anemia. The generation of induced pluripotent stem cells (iPSCs) from the somatic cells of patients in combination with subsequent homologous recombination-based gene correction provides ne...

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Detaylı Bibliyografya
Yayımlandı:Sci Rep
Asıl Yazarlar: Ou, Zhanhui, Niu, Xiaohua, He, Wenyin, Chen, Yuchang, Song, Bing, Xian, Yexing, Fan, Di, Tang, Daolin, Sun, Xiaofang
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Nature Publishing Group 2016
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5007518/
https://ncbi.nlm.nih.gov/pubmed/27581487
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep32463
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