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Loss of the Spinocerebellar Ataxia type 3 disease protein ATXN3 alters transcription of multiple signal transduction pathways

Spinocerebellar ataxia type 3 (SCA3) is a dominantly inherited neurodegenerative disorder caused by a polyglutamine-encoding CAG repeat expansion in the ATXN3 gene which encodes the deubiquitinating enzyme, ATXN3. Several mechanisms have been proposed to explain the pathogenic role of mutant, polyQ-...

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Publicat a:PLoS One
Autors principals: Zeng, Li, Zhang, Dapeng, McLoughlin, Hayley S., Zalon, Annie J., Aravind, L., Paulson, Henry L.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2018
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6145529/
https://ncbi.nlm.nih.gov/pubmed/30231063
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0204438
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