Autophagy Promoted the Degradation of Mutant ATXN3 in Neurally Differentiated Spinocerebellar Ataxia-3 Human Induced Pluripotent Stem Cells

Spinocerebellar ataxia-3 (SCA3) is the most common dominant inherited ataxia worldwide and is caused by an unstable CAG trinucleotide expansion mutation within the ATXN3 gene, resulting in an expanded polyglutamine tract within the ATXN3 protein. Many in vitro studies have examined the role of autop...

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Veröffentlicht in:Biomed Res Int
Hauptverfasser: Ou, Zhanhui, Luo, Min, Niu, Xiaohua, Chen, Yuchang, Xie, Yingjun, He, Wenyin, Song, Bing, Xian, Yexing, Fan, Di, OuYang, Shuming, Sun, Xiaofang
Format: Artigo
Sprache:Inglês
Veröffentlicht: Hindawi Publishing Corporation 2016
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5099487/
https://ncbi.nlm.nih.gov/pubmed/27847820
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2016/6701793
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