RNA polymerase II senses obstruction in the DNA minor groove via a conserved sensor motif

RNA polymerase II (pol II) encounters numerous barriers during transcription elongation, including DNA strand breaks, DNA lesions, and nucleosomes. Pyrrole-imidazole (Py-Im) polyamides bind to the minor groove of DNA with programmable sequence specificity and high affinity. Previous studies suggest...

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Bibliographic Details
Published in:Proc Natl Acad Sci U S A
Main Authors: Xu, Liang, Wang, Wei, Gotte, Deanna, Yang, Fei, Hare, Alissa A., Welch, Timothy R., Li, Benjamin C., Shin, Ji Hyun, Chong, Jenny, Strathern, Jeffrey N., Dervan, Peter B., Wang, Dong
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2016
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5098678/
https://ncbi.nlm.nih.gov/pubmed/27791148
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1612745113
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