Crystal structure of a LacY–nanobody complex in a periplasmic-open conformation

The lactose permease of Escherichia coli (LacY), a dynamic polytopic membrane protein, catalyzes galactoside–H(+) symport and operates by an alternating access mechanism that exhibits multiple conformations, the distribution of which is altered by sugar binding. We have developed single-domain camel...

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Dades bibliogràfiques
Publicat a:Proc Natl Acad Sci U S A
Autors principals: Jiang, Xin, Smirnova, Irina, Kasho, Vladimir, Wu, Jianping, Hirata, Kunio, Ke, Meng, Pardon, Els, Steyaert, Jan, Yan, Nieng, Kaback, H. Ronald
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2016
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5098631/
https://ncbi.nlm.nih.gov/pubmed/27791182
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1615414113
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