Mimetics of brain-derived neurotrophic factor loops 1 and 4 are active in a model of ischemic stroke in rats

BACKGROUND: Two dimeric dipeptides, bis-(N-monosuccinyl-l-seryl-l-lysine)hexamethylenediamide (GSB-106) and bis-(N-monosuccinyl-l-methionyl-l-serine) heptamethylenediamide (GSB-214), were designed based on the brain-derived neurotrophic factor (BDNF) loop 4 and loop 1 β-turn sequences, respectively....

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Detalhes bibliográficos
Publicado no:Drug Des Devel Ther
Main Authors: Gudasheva, Tatyana A, Povarnina, Polina, Logvinov, Ilya O, Antipova, Tatyana A, Seredenin, Sergey B
Formato: Artigo
Idioma:Inglês
Publicado em: Dove Medical Press 2016
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Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5098525/
https://ncbi.nlm.nih.gov/pubmed/27843294
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/DDDT.S118768
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