Dimeric dipeptide mimetics of the nerve growth factor Loop 4 and Loop 1 activate TRKA with different patterns of intracellular signal transduction

BACKGROUND: This study aimed at developing nerve growth factor (NGF) mimetics that selectively activate specific biological signals and, as a result, lack the side effects of the full-length protein. Two dimeric dipeptides, bis-(N-aminocaproyl-glycyl-L-lysine) hexamethylenediamide (GK-6) and bis(N-s...

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Detalhes bibliográficos
Publicado no:J Biomed Sci
Main Authors: Gudasheva, Tatyana A., Povarnina, Polina Yu, Antipova, Tatyana A., Firsova, Yulia N., Konstantinopolsky, Mark A., Seredenin, Sergey B.
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2015
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4672491/
https://ncbi.nlm.nih.gov/pubmed/26642930
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12929-015-0198-z
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