Low-Molecular Weight BDNF Mimetic, Dimeric Dipeptide GSB-106, Reverses Depressive Symptoms in Mouse Chronic Social Defeat Stress

A mimetic of the BDNF loop 4, bis (N-monosuccinyl-L-seryl-L-lysine) hexamethylenediamide, named GSB-106, was designed and synthesized in our scientific group. The compound activated TrkB, MAPK/ERK, PI3K/AKT, and PLCγ in in vitro experiments. In vivo experiments with rodents revealed its antidepressa...

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Detalhes bibliográficos
Publicado no:Biomolecules
Main Authors: Gudasheva, Tatiana A., Tallerova, Anna V., Mezhlumyan, Armen G., Antipova, Tatyana A., Logvinov, Ilya O., Firsova, Yulia N., Povarnina, Polina Y., Seredenin, Sergey B.
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7916338/
https://ncbi.nlm.nih.gov/pubmed/33578683
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/biom11020252
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