Mimetics of brain-derived neurotrophic factor loops 1 and 4 are active in a model of ischemic stroke in rats

BACKGROUND: Two dimeric dipeptides, bis-(N-monosuccinyl-l-seryl-l-lysine)hexamethylenediamide (GSB-106) and bis-(N-monosuccinyl-l-methionyl-l-serine) heptamethylenediamide (GSB-214), were designed based on the brain-derived neurotrophic factor (BDNF) loop 4 and loop 1 β-turn sequences, respectively....

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Dettagli Bibliografici
Pubblicato in:Drug Des Devel Ther
Autori principali: Gudasheva, Tatyana A, Povarnina, Polina, Logvinov, Ilya O, Antipova, Tatyana A, Seredenin, Sergey B
Natura: Artigo
Lingua:Inglês
Pubblicazione: Dove Medical Press 2016
Soggetti:
Original Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5098525/
https://ncbi.nlm.nih.gov/pubmed/27843294
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/DDDT.S118768
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